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PD0166285 dihydrochloride

Catalog No. T6931L CAS 212391-63-4

Synonyms: PD-166285

PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PD0166285 dihydrochloride Chemical Structure

PD0166285 dihydrochloride, CAS 212391-63-4

Pack Size	Availability	Price/USD	Quantity
1 mg	35 days	$ 93.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.
Targets&IC50	Chk1:3.433 μM (IC50), Myt1:72 nM (IC50), Wee1:24 nM (IC50)

Synonyms	PD-166285
Molecular Weight	585.35
Formula	C26H29Cl4N5O2
CAS No.	212391-63-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Leijen S, Beijnen JH, Schellens JH. Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents. Curr Clin Pharmacol. 2010 Aug;5(3):186-91. Review. PubMed PMID: 20406171. 2. Furet P, Caravatti G, Guagnano V, Lang M, Meyer T, Schoepfer J. Entry into a new class of protein kinase inhibitors by pseudo ring design. Bioorg Med Chem Lett. 2008 Feb 1;18(3):897-900. doi: 10.1016/j.bmcl.2007.12.041. Epub 2008 Jan 14. PubMed PMID: 18248988. 3. Lavelle F. American Association for Cancer Research 1999: 10-14 April, Philadelphia, Pennsylvania. Expert Opin Investig Drugs. 1999 Jun;8(6):903-9. PubMed PMID: 15992139. 4. Dimitroff CJ, Klohs W, Sharma A, Pera P, Driscoll D, Veith J, Steinkampf R, Schroeder M, Klutchko S, Sumlin A, Henderson B, Dougherty TJ, Bernacki RJ. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999;17(2):121-35. PubMed PMID: 10638483.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PD0166285 dihydrochloride 212391-63-4 PD-0166285 Dihydrochloride PD 166285 PD-0166285 PD-0166285 dihydrochloride PD0166285 PD0166285 Dihydrochloride PD 0166285 Dihydrochloride PD 0166285 PD-166285 PD166285 inhibitor inhibit

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