Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.
Description | Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases. |
Targets&IC50 | JAK1-dependent:36 to 249 nM, JAK family members:10 to 99 nM |
In vitro | PF-03394197 inhibits JAK family members by 50% at concentrations ranging from 10 to 99 nM and does not inhibit a panel of 38 non-JAK kinases. PF-03394197 is most potent at inhibiting JAK1. PF-03394197 also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. PF-03394197 has minimal effects on cytokines which does not activate the JAK1 enzyme in cells[1]. |
In vivo | PF-03394197 administered orally at a dose of 0.4–0.6 mg/kg twice daily is safe and efficacious in controlling the pruritus associated with allergic dermatitis. PF-03394197 provides itch relief within 24 h that persistes through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7[2]. |
Synonyms | PF-03394197, 奥拉替尼马来酸盐, PF-03394197 maleate |
Molecular Weight | 453.51 |
Formula | C19H27N5O6S |
CAS No. | 1640292-55-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 15 mg/mL (33.1 mM)
Ethanol: 83 mg/mL (183 mM)
DMSO: 83 mg/mL (183 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Oclacitinib maleate 1640292-55-2 JAK/STAT信号通路 表观遗传 蛋白酪氨酸激酶 干细胞 血管生成 Tyrosine Kinases JAK Oclacitinib PF03394197 inhibit PF 03394197 Inhibitor PF-03394197 PF-03394197 maleate Janus kinase inhibitor