Powder: -20°C for 3 years
In solvent: -80°C for 2 years
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Description | OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ. |
In vitro | OP-1074 as a pure antiestrogen and a selective ER degrader (PA-SERD) that is efficacious in shrinking tumors in a tamoxifen-resistant xenograft model. Biochemical and crystal structure analyses reveal a structure activity relationship implicating the importance of a stereospecific methyl on the pyrrolidine side chain of OP-1074, particularly on helix 12. |
Molecular Weight | 457.56 |
Formula | C29H31NO4 |
CAS No. | 1443752-76-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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OP-1074 1443752-76-8 Endocrinology/Hormones Estrogen/progestogen Receptor OP 1074 OP1074 Inhibitor inhibitor inhibit