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Nicaraven

Catalog No. T6606 CAS 79455-30-4

Nicaraven, a hydroxyl radical scavenger, has neuroprotective and antivasospastic effects.

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Nicaraven, CAS 79455-30-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 35.00
25 mg	In stock	$ 47.00
50 mg	In stock	$ 56.00
100 mg	In stock	$ 109.00
200 mg	In stock	$ 207.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nicaraven, a hydroxyl radical scavenger, has neuroprotective and antivasospastic effects.
In vitro	Nicaraven causes a dose-dependent, slight inhibition of poly (ADP-ribose) synthetase activation, possibly due to a direct inhibitory effect on the catalytic activity of poly (ADP-ribose) synthetase in RAW murine macrophages stimulated with peroxynitrite. Nicaraven partially protects against the peroxynitrite-induced suppression of mitochondrial respiration in RAW macrophages and causes a slight, dose-dependent inhibition of nitrite production in RAW macrophages stimulated with bacterial lipopolysaccharide. [1] Nicaraven (0.35 mM) significantly inhibits the maximum aggregation rate induced by adenosine diphosphate (ADP) in the healthy volunteer platelets. Nicaraven (1.75 mM) significantly reduces the maximum aggregation rate induced by collagen in platelets. Nicaraven induces dose-dependent inhibition of platelet aggregation in both healthy volunteers and patients with cerebral thrombosis. [2]
In vivo	Nicaraven inhibits lipid peroxidation in the liver of beagle dogs, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. [3] Nicaraven (20 mg/kg) elicits small reductions in infarction volume in male Sprague-Dawley rats subjected to transient focal ischemia. Nicaraven (60 mg/kg) provides significant reductions in the volume of infarction (18.6% and 20.9%) reductions for the pre- and posttreatment groups, respectively, in male Sprague-Dawley rats subjected to transient focal ischemia. [4]

Molecular Weight	284.31
Formula	C15H16N4O2
CAS No.	79455-30-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 53 mg/mL (186.4 mM)

H2O: 52 mg/mL (182.9 mM)

DMSO: 53 mg/mL (186.4 mM)

References and Literature

1. Zingarelli B, et al. Shock, 2000, 13(2), 126-134. 2. Komiya T, et al. Clin Neuropharmacol, 1999, 22(1), 11-14. 3. Yokota R, et al. Surgery, 2000, 127(6), 661-669. 4. Toyoda T, et al. Neurosurgery, 1997, 40(2), 372-377.

Related compound libraries

This product is contained In the following compound libraries：

Human Metabolite Library Ferroptosis Compound Library ReFRAME Related Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Nicaraven 79455-30-4 Others Inhibitor inhibit inhibitor

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