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N6022

Catalog No. T6901 CAS 1208315-24-5

N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.

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N6022, CAS 1208315-24-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 40.00
2 mg	In stock	$ 55.00
5 mg	In stock	$ 96.00
10 mg	In stock	$ 140.00
25 mg	In stock	$ 273.00
50 mg	In stock	$ 453.00
100 mg	In stock	$ 667.00
500 mg	In stock	$ 1,420.00
1 mL * 10 mM (in DMSO)	In stock	$ 100.00

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Purity: 98.32%

Purity: 98.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.
Targets&IC50	GSNOR:8 nM
In vitro	N6022 binds to rat plasma proteins in a concentration-dependent manner. At lower drug concentrations (20 μM), N6022 show more effect on ATP than on GSH. N6022 (IC50 of 8 nM and a Ki of 2.5 nM) binds in the GSNO substrate binding pocket like a competitive inhibitor. N6022 is uncompetitive with cofactors NAD+ and NADH.
In vivo	N6022 treats rats in 50 mg/kg leading to a slight increase in the incidence of granulomas. In serum, N6022 remained in solution is up to 5 mg/mL.
Cell Research	N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis.

Molecular Weight	414.46
Formula	C24H22N4O3
CAS No.	1208315-24-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46 mg/mL

References and Literature

1. Green LS, et al. Biochemistry. 2012, 51(10), 2157-2168 2. Sun X, et al. ACS Med Chem Lett. 2011, 2(5), 402-406.

Citations

1. Liu Q, Gu T, Su L Y, et al. GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. Redox Biology. 2021: 102172.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library ReFRAME Related Library Metabolism Compound Library Clinical Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

N6022 1208315-24-5 Metabolism GSNOR Inhibitor N-6022 N 6022 inhibit S-nitrosoglutathione reductase inhibitor

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