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Metabolism GSNOR N6022

N6022

Catalog No. T6901   CAS 1208315-24-5

N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.

N6022, CAS 1208315-24-5
Pack Size Availability Price/USD Quantity
2 mg Inquiry 62.00
5 mg In stock 112.00
10 mg In stock 156.00
25 mg In stock 360.00
50 mg In stock 504.00
100 mg In stock 753.00
1 mL * 10 mM (in DMSO) Inquiry 112.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.
Targets&IC50 S-nitrosoglutathione reductase (GSNOR) : ic50 8nM,  
In vivo N6022 treats rats in 50 mg/kg leading to a slight increase in the incidence of granulomas. In serum, N6022 remained in solution is up to 5 mg/mL.
Cell Research
N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis.
Animal Research
Animal Model: Mouse model of asthm.
Molecular Weight 414.46
Formula C24H22N4O3
CAS No. 1208315-24-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 46 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Green LS, et al. Biochemistry. 2012, 51(10), 2157-2168 2. Sun X, et al. ACS Med Chem Lett. 2011, 2(5), 402-406. 3. Thomas M. Raffay, et al. Methods of treating respiratory disorders. Patent. US 20170209419 A1.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Clinical Compound Library Anti-Metabolism Disease Compound Library

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N6022

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