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Mosapride citrate dihydrate

Catalog No. T6597L CAS 636582-62-2

Synonyms: GR-107719-B, Mosapride Citrate, GR 107719 B, AS 4370, AS-4370, TAK-370

Mosapride Citrate is a 5-HT4 receptor agonist used to stimulate gastrointestinal motility via acetylcholine. Mosapride Citrate facilitates acetylcholine release from the enteric cholinergic neurons.

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Mosapride citrate dihydrate Chemical Structure

Mosapride citrate dihydrate, CAS 636582-62-2

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Biological Description

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Storage & Solubility Information

Description

Mosapride Citrate is a 5-HT4 receptor agonist used to stimulate gastrointestinal motility via acetylcholine. Mosapride Citrate facilitates acetylcholine release from the enteric cholinergic neurons.

Synonyms	GR-107719-B, Mosapride Citrate, GR 107719 B, AS 4370, AS-4370, TAK-370
Molecular Weight	632.04
Formula	C27H35ClFN3O11
CAS No.	636582-62-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Maruoka D, Arai M, Tanaka T, Okimoto K, Oyamada A, Minemura S, Tsuboi M, Matsumura T, Nakagawa T, Kanda T, Katsuno T, Imazeki F, Yokosuka O. Mosapride citrate increases postprandial glucagon-like peptide-1, insulin, and gene expression of sweet taste receptors. Dig Dis Sci. 2015 Feb;60(2):345-53. doi: 10.1007/s10620-014-3271-7. Epub 2014 Jul 10. PubMed PMID: 25008428. 2. Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM. Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay. Biomol Ther (Seoul). 2015 Sep;23(5):486-92. doi: 10.4062/biomolther.2015.041. Epub 2015 Sep 1. PubMed PMID: 26336590; PubMed Central PMCID: PMC4556210. 3. Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G151-8. doi: 10.1152/ajpgi.00198.2014. Epub 2014 Nov 26. PubMed PMID: 25428903. 4. Aoki K, Kamiyama H, Masuda K, Togashi Y, Terauchi Y. Mosapride citrate, a 5-HT₄ receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men. Endocr J. 2013;60(4):493-9. Epub 2012 Dec 18. PubMed PMID: 23257734.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mosapride citrate dihydrate 636582-62-2 Mosapride citrate Dihydrate GR-107719-B Mosapride Citrate GR 107719 B AS 4370 TAK370 AS-4370 TAK-370 TAK 370 AS4370 inhibitor inhibit

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