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Mexiletine

Catalog No. T21427 CAS 31828-71-4

Synonyms: Mexitil, Mexiletene, KO-1173, KO1173, KO 1173

Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mexiletine, CAS 31828-71-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Mexitil, Mexiletene, KO-1173, KO1173, KO 1173
Molecular Weight	179.26
Formula	C11H17NO
CAS No.	31828-71-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Soluble

References and Literature

1. Catalano A, Carocci A, Sinicropi MS. Mexiletine metabolites: a review. Curr Med Chem. 2015;22(11):1400-13. Review. PubMed PMID: 25723511. 2. Gao Y, Xue X, Hu D, Liu W, Yuan Y, Sun H, Li L, Timothy KW, Zhang L, Li C, Yan GX. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome. Circ Arrhythm Electrophysiol. 2013 Jun;6(3):614-22. doi: 10.1161/CIRCEP.113.000092. Epub 2013 Apr 11. Review. PubMed PMID: 23580742. 3. Marmura MJ. Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias. Curr Pain Headache Rep. 2010 Apr;14(2):145-50. doi: 10.1007/s11916-010-0098-6. Review. PubMed PMID: 20425204. 4. Ebell MH. Systemic lidocaine or mexiletine for neuropathic pain. Am Fam Physician. 2006 Jul 1;74(1):79. Review. PubMed PMID: 16848381.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mexiletine 31828-71-4 Mexitil Mexiletene KO-1173 KO1173 KO 1173 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.