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Metolachlor

Name: Metolachlor
Brand: TargetMol
SKU: T19891
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19891Cas No. 51218-45-2

Metolachlor is an organic compound. Metolachlor is also widely used as an herbicide.

Metolachlor

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Purity: 98.69%

Catalog No. T19891Cas No. 51218-45-2

Metolachlor is an organic compound. Metolachlor is also widely used as an herbicide.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.69%

Appearance:Viscous

Color:Transparent

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COA HNMR LCMS

Product Introduction

Metolachlor AI Summary

Metolachlor is a multifaceted bioactive molecule exhibiting a wide range of activities. It functions as: - An antagonist of androgen receptor signaling with a potency of 19952.6 nM. - An agonist of peroxisome proliferator-activated receptor delta signaling with a potency of 44668.4 nM. - An antagonist of peroxisome proliferator-activated receptor gamma signaling with a potency of 44668.4 nM. - An antagonist of peroxisome proliferator-activated receptor delta signaling with a potency of 39810.7 nM. - An agonist of peroxisome proliferator-activated receptor gamma signaling with a potency of 39810.7 nM. - An agonist of the antioxidant response element (ARE) signaling pathway, with potencies of 24336.5 nM and 38570.8 nM measured by Nrf2-dependent transcriptional activity. - An inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 29092.9 nM in the presence of CPT. - An activator of the human pregnane X receptor (PXR) signaling pathway with a potency of 562.3 nM. It also exhibits notable herbicidal properties: - Inhibits desalted triosephosphate isomerase in Lolium multiflorum (Italian rye grass) shoots, with an activity of 9.57 nmol/sec per mg protein. - Demonstrates strong pre- and post-emergence herbicidal activity against species such as Digitaria sanguinalis, Echinochloa crus-galli, Amaranthus retroflexus, Brassica rapa subsp. oleifera, and others, showing effective inhibition at specified concentrations. - Exhibits selectivity, showing low toxicity against crop species like Zea mays var. SHEN DAN 17 and Brassica rapa subsp. oleifera var. JING GUAN 1. Additionally, Metolachlor binds to the SafBP receptor in Zea mays seedlings with an IC50 value of 39810717.06 nM and potently inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 µM, with inhibition percentages of 93.33% and 101.68%, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Metolachlor is an organic compound. Metolachlor is also widely used as an herbicide.

Chemical Properties

Molecular Weight	283.79
Formula	C₁₅H₂₂ClNO₂
Cas No.	51218-45-2
Smiles	CCc1cccc(C)c1N(C(C)COC)C(=O)CCl
Relative Density.	1.1200 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (229.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5237 mL	17.6187 mL	35.2373 mL	176.1866 mL
5 mM	0.7047 mL	3.5237 mL	7.0475 mL	35.2373 mL
10 mM	0.3524 mL	1.7619 mL	3.5237 mL	17.6187 mL
20 mM	0.1762 mL	0.8809 mL	1.7619 mL	8.8093 mL
50 mM	0.0705 mL	0.3524 mL	0.7047 mL	3.5237 mL
100 mM	0.0352 mL	0.1762 mL	0.3524 mL	1.7619 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc