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Melanotan (MT)-II

Catalog No. TP1324 CAS 121062-08-6

Synonyms: 美拉诺坦 (MT)-II, 美拉诺坦 II

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).

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Melanotan (MT)-II, CAS 121062-08-6

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Purity: 98%

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Description	Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).
In vitro	Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems, for example, the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system[1].
In vivo	Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thus exerting a facilitator effect on erection[2]. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg[3]. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction[4]. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model[5].

Synonyms	美拉诺坦 (MT)-II, 美拉诺坦 II
Molecular Weight	1024.18
Formula	C50H69N15O9
CAS No.	121062-08-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Breindahl T, et al. Identification and characterization by LC-UV-MS/MS of melanotan II skin-tanning products sold illegally on the Internet. Drug Test Anal. 2015 Feb;7(2):164-72.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Macrocyclic Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

HS 014 acetate(207678-81-7 free base) HS024 [D-Trp8]-γ-MSH acetate(321351-81-9 free base) Melanotan (MT)-II ACTH 11-24 acetate(4237-93-8 free base) α-MSH Adrenocorticotropic Hormone (ACTH) (4-10), human Bremelanotide Acetate

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Keywords

Melanotan (MT)-II 121062-08-6 G蛋白偶联受体神经科学 Melanocortin Receptor Inhibitor inhibit Melanotan (MT)II Melanotan (MT) II inhibitor

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