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Melanotan (MT)-II

Melanotan (MT)-II
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Purity:100%
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Melanotan (MT)-II

Catalog No. TP1324Cas No. 121062-08-6
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).
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Pack SizePriceAvailabilityQuantity
2 mg$42In Stock
5 mg$68In Stock
10 mg$100In Stock
25 mg$175In Stock
50 mg$277In Stock
100 mg$467In Stock
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Product Introduction

Bioactivity
Description
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).
In vitro
Melanotan-II (MT-II) acts as a powerful, non-selective agonist targeting melanocortin receptors (MC1, MC3, MC4, and MC5), which play crucial roles in various physiological systems including pigmentation, energy balance, sexual health, immune response, inflammation, and cardiovascular function[1].
In vivo
Melanotan (MT)-II functions as a potent inducer of penile erection, demonstrating dose-dependent activity. It reduces the time until the first erectile event and enhances erectile responses following cavernous nerve stimulation. Research indicates that at a dosage of 1 mg/kg intravenously, MT-II facilitates erection by increasing the erectile response. Additionally, MT-II has been shown to possess neuroprotective qualities and promote peripheral nerve regeneration, particularly highlighted by its significant enhancement of sensory function recovery in rats after sciatic nerve damage when administered at 20 μg/kg every 48 hours subcutaneously. In cases of erectile dysfunction in men, MT-II has proven to be an effective initiator of penile erection. Beyond its effects on erectile and sensory functions, MT-II also impacts metabolic parameters, notably reducing food intake and body weight, while inducing thermogenic responses in mouse models.
Chemical Properties
Molecular Weight1024.18
FormulaC50H69N15O9
Cas No.121062-08-6
Storage & Solubility Information
Storagekeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 10mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9764 mL4.8820 mL9.7639 mL48.8195 mL
5 mM0.1953 mL0.9764 mL1.9528 mL9.7639 mL

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