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Mal-amido-PEG8-NHS ester

Name: Mal-amido-PEG8-NHS ester
Brand: TargetMol
SKU: T15962
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15962Cas No. 756525-93-6

Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Mal-amido-PEG8-NHS ester

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Purity: 98.65%

Catalog No. T15962Cas No. 756525-93-6

Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$33	In Stock	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.65%

Appearance:Viscous

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.
In vitro	PROTACs comprise two ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	689.71
Formula	C₃₀H₄₇N₃O₁₅
Cas No.	756525-93-6
Smiles	O(C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(=O)C=CC1=O)=O)=O)N2C(=O)CCC2=O
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (362.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4499 mL	7.2494 mL	14.4988 mL	72.4942 mL
5 mM	0.2900 mL	1.4499 mL	2.8998 mL	14.4988 mL
10 mM	0.1450 mL	0.7249 mL	1.4499 mL	7.2494 mL
20 mM	0.0725 mL	0.3625 mL	0.7249 mL	3.6247 mL
50 mM	0.0290 mL	0.1450 mL	0.2900 mL	1.4499 mL
100 mM	0.0145 mL	0.0725 mL	0.1450 mL	0.7249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc