Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 258.00 | |
5 mg | In stock | $ 642.00 | |
10 mg | In stock | $ 913.00 | |
25 mg | In stock | $ 1,370.00 | |
50 mg | In stock | $ 1,850.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 733.00 |
Description | LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A. |
Targets&IC50 | LMPTP-A:0.8 μM |
In vitro | LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1]. |
In vivo | LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1]. |
Synonyms | LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) |
Molecular Weight | 481.07 |
Formula | C28H37ClN4O |
CAS No. | 2310135-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (18.71 mM)
You can also refer to dose conversion for different animals. More
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LMPTP INHIBITOR 1 hydrochloride 2310135-38-5 Metabolism Phosphatase LMPTP INHIBITOR 1 Hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) inhibitor inhibit