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LMPTP INHIBITOR 1 hydrochloride

Catalog No. T4491   CAS 2310135-38-5
Synonyms: LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A.

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LMPTP INHIBITOR 1 hydrochloride Chemical Structure
LMPTP INHIBITOR 1 hydrochloride, CAS 2310135-38-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 258.00
5 mg In stock $ 642.00
10 mg In stock $ 913.00
25 mg In stock $ 1,370.00
50 mg In stock $ 1,850.00
1 mL * 10 mM (in DMSO) In stock $ 733.00
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Purity: 99.63%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A.
Targets&IC50 LMPTP-A:0.8 μM
In vitro LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1].
In vivo LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1].
Synonyms LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))
Molecular Weight 481.07
Formula C28H37ClN4O
CAS No. 2310135-38-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (18.71 mM)

TargetMolReferences and Literature

1. Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632.

Related compound libraries

This product is contained In the following compound libraries:
Phosphatase Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library Glycometabolism Compound Library

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Keywords

LMPTP INHIBITOR 1 hydrochloride 2310135-38-5 Metabolism Phosphatase LMPTP INHIBITOR 1 Hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) inhibitor inhibit

 

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