Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 33.00 | |
50 mg | In stock | $ 47.00 | |
100 mg | In stock | $ 80.00 |
Description | L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. |
Targets&IC50 | Ovarian tumor:29 μM, Breast:8.6 μM, Melanoma:1.9 μM |
In vitro | IC50 values (microM) for L-buthionine-S,R-sulfoximine (BSO) on melanoma, breast and ovarian tumor specimens were 1.9, 8.6, and 29, respectively. The IC90 for melanoma was 25.5 microM, a level 20-fold lower than steady-state levels achieved clinically [1]. GSH loss induced by L-buthionine-S,R-sulfoximine (BSO) leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells [2]. |
In vivo | Systemic BSO administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6?mmol/kg of BSO depleted GSH and GSSG in the liver at 2?h of treatment [3]. |
Synonyms | L-Butionine sulfoximine |
Molecular Weight | 222.31 |
Formula | C8H18N2O3S |
CAS No. | 83730-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
L-BUTHIONINE-(S,R)-SULFOXIMINE 83730-53-4 Apoptosis Others Ferroptosis stress GSH L-Butionine sulfoximine Inhibitor eye-spot inhibit oxidative L-BUTHIONINE-SULFOXIMINE glutamylcysteine LBUTHIONINE(S,R)SULFOXIMINE L BUTHIONINE (S,R) SULFOXIMINE L-BSO L-Buthionine sulfoximine BSO inhibitor