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K-80003

Catalog No. T11734 CAS 1292821-90-9

Synonyms: TX-803

K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.

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K-80003, CAS 1292821-90-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 77.00
5 mg	In stock	$ 125.00
10 mg	In stock	$ 183.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 453.00
100 mg	In stock	$ 667.00
500 mg	In stock	$ 1,420.00
1 mL * 10 mM (in DMSO)	In stock	$ 135.00

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Purity: 99.76%

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Description	K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
In vitro	In MCF-7 cells, cotreatment with K-80003 inhibits the TNFα-induced colocalization of tRXRα with p85α in the cytoplasm, leading to tRXRα nuclear localization. Western blotting reveals that the K-80003-stabilized tetrameric form of tRXRα is exclusively present in the nuclear fraction, while the tRXRα monomer is distributed in both nuclear and cytoplasmic fractions [1].
In vivo	K-80003, a potent inhibitor of AKT activation by all-trans-retinoic acid, exhibits enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity for RXRα but lacks COX inhibitory activity [2].

Synonyms	TX-803
Molecular Weight	336.4
Formula	C22H21FO2
CAS No.	1292821-90-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (59.45 mM), Sonication is recommended.

References and Literature

1. Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066. 2. Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max

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Keywords

K-80003 1292821-90-9 Cytoskeletal Signaling Metabolism PI3K/Akt/mTOR signaling RAR/RXR Akt TX-803 K 80003 TX 803 TX803 K80003 inhibitor inhibit

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