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Isolicoflavonol

Catalog No. TN1783   CAS 94805-83-1

Isolicoflavonol inhibits Human carboxylesterase 2 (hCES2A) which is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent.

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Isolicoflavonol Chemical Structure
Isolicoflavonol, CAS 94805-83-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isolicoflavonol inhibits Human carboxylesterase 2 (hCES2A) which is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent.
Targets&IC50 Human carboxylesterase 2 (hCES2A):<1.0 μM(Ki)
In vitro Using a panel of in vitro bioassays to monitor chromatographic fractionation, a diverse group of plant secondary metabolites has been identified as potential cancer chemopreventive agents from mainly edible plants. Nearly 50 new compounds have been isolated as bioactive principles in one or more in vitro bioassays in work performed over the last five years. Included among these new active compounds are alkaloids, flavonoids, stilbenoids, and withanolides, as well as a novel stilbenolignan and the first representatives of the norwithanolides, which have a 27-carbon atom skeleton. In addition, over 100 active compounds of previously known structure have been obtained. Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids. Several of the bioactive compounds were found to be active when evaluated in a mouse mammary organ culture assay, when used as a secondary discriminator in our work.
Source
Molecular Weight 354.35
Formula C20H18O6
CAS No. 94805-83-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Kinghorn AD, et al. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug;70(8):691-705. 2. Song YQ, et al. Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays. Food Funct. 2021;12(1):162-176.

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Keywords

Isolicoflavonol 94805-83-1 Metabolism Lipid inhibit Inhibitor inhibitor

 

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