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Hypoxanthine

Catalog No. T1362   CAS 68-94-0
Synonyms: Sarcine, Sarkin, Purin-6-ol, 6-Hydroxypurine, 6-羟基嘌呤

Hypoxanthine, a purine derivative, is a potential free radical generator. It has been used in studies as in indicator, along with uric acid and allantoin, of in vivo free radical reactions.

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Hypoxanthine, CAS 68-94-0
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hypoxanthine, a purine derivative, is a potential free radical generator. It has been used in studies as in indicator, along with uric acid and allantoin, of in vivo free radical reactions.
In vitro Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary additive in a certain cell, bacteria, and parasite cultures as a substrate and nitrogen source. [1]
In vivo A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit[1].
Synonyms Sarcine, Sarkin, Purin-6-ol, 6-Hydroxypurine, 6-羟基嘌呤
Molecular Weight 136.114
Formula C5H4N4O
CAS No. 68-94-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: Insoluble

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Saugstad OD, Pediatr Res, 1988, 23(2), 143-150. 2. Skolnick P, et al. Life Sci, 1978, 23(14), 1473-1480.

Related compound libraries

This product is contained In the following compound libraries:
Gut Microbial Metabolite Library Drug Metabolite/Impurity Library Traditional Chinese Medicine Monomer Library Human Endogenous Metabolite Library Natural Product Library for HTS Nucleotide Compound Library Alkaloid Natural Product Library Anti-Viral Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Keywords

Hypoxanthine 68-94-0 代谢 其他 Endogenous Metabolite Others Sarkin Purin-6-ol inhibit 6-Hydroxypurine Sarcine Inhibitor inhibitor