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HS38

Catalog No. T27554 CAS 1030203-81-6

Synonyms: HS-38, HS 38

HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.

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HS38, CAS 1030203-81-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Targets&IC50	DAPK2:79 nM (Kd), ZIPK:280 nM (Kd), Pim3:200 nM (Kd), DAPK1:300 nM (Kd), DAPK1:IC50 : 200 nM
In vitro	HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1].

Synonyms	HS-38, HS 38
Molecular Weight	349.79
Formula	C14H12ClN5O2S
CAS No.	1030203-81-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 6.4 mg/mL (18.4 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. MacDonald JA, et al. A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol Pharmacol. 2016 Jan;89(1):105-17. 2. David A Carlson, et al. Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor. ACS Chem Biol. 2013 Dec 20; 8(12): 2715–2723. 3. Lorenz E, Lastovica A, Owen RJ. Subtyping of Campylobacter jejuni Penner serotypes 9, 38 and 63 from human infections, animals and water by pulsed field gel electrophoresis and flagellin gene analysis. Lett Appl Microbiol. 1998 Mar;26(3):179-82.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HS38 1030203-81-6 HS-38 HS 38 Inhibitor inhibitor inhibit

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