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HS38

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Purity:95.53%

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COA HNMR HPLC

HS38

Catalog No. T27554Cas No. 1030203-81-6

HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$67	In Stock
25 mg	$138	In Stock
50 mg	$222	In Stock
100 mg	$361	In Stock
200 mg	$538	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
In vitro	HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1].
Alias	HS 38, HS-38

Chemical Properties

Molecular Weight	349.8
Formula	C14H12ClN5O2S
Cas No.	1030203-81-6

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.4 mg/mL (18.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8588 mL	14.2939 mL	28.5878 mL	142.9388 mL
5 mM	0.5718 mL	2.8588 mL	5.7176 mL	28.5878 mL
10 mM	0.2859 mL	1.4294 mL	2.8588 mL	14.2939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc