Powder: -20°C for 3 years
In solvent: -80°C for 2 years
HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Description | HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders. |
Targets&IC50 | DAPK2:79 nM (Kd), ZIPK:280 nM (Kd), Pim3:200 nM (Kd), DAPK1:300 nM (Kd), DAPK1:IC50 : 200 nM |
In vitro | HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1]. |
Synonyms | HS-38, HS 38 |
Molecular Weight | 349.79 |
Formula | C14H12ClN5O2S |
CAS No. | 1030203-81-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 6.4 mg/mL (18.4 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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HS38 1030203-81-6 HS-38 HS 38 Inhibitor inhibitor inhibit