Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 970.00 | |
50 mg | 8-10 weeks | $ 1,260.00 | |
100 mg | 8-10 weeks | $ 1,910.00 |
Description | GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity. |
Targets&IC50 | MCH R1:(pic50)9.3 |
In vitro | GW-803430 shows a potent antagonist activity towards MCH induced MCHR1 receptor (IC50: ~13?nM)[2]. |
In vivo | GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain: plasma concentration) in mice. GW-803430 (0.3, 3, and 15 mg/kg; p.o.; once daily) induces a sustained dose-dependent weight loss relative to vehicle controls [1]. |
Synonyms | GW-3430 |
Molecular Weight | 481.99 |
Formula | C25H24ClN3O3S |
CAS No. | 515141-51-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GW-803430 515141-51-2 Others GW-3430 GW803430 GW3430 GW 803430 GW 3430 inhibitor inhibit