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Fructosyl-lysine

Catalog No. T15350 CAS 21291-40-7

Synonyms: Fructoselysine

Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction.

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Fructosyl-lysine, CAS 21291-40-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 954.00
50 mg	6-8 weeks	$ 1,240.00
100 mg	6-8 weeks	$ 1,740.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction.
In vitro	Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in?E?.coli extracts. Fructosyl-lysine (25 mM; 25 hours) lets E. coli?growth at a rate of about one-third of that observed with glucose as a carbon source. Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products showing the existence of a fructoselysine-kinase activity in E?.coli extracts [2].
In vivo	In diabetic rats, Fructosyl-lysine and AGE residues are increased markedly in glomeruli, sciatic nerve, retina, and plasma protein [1].

Synonyms	Fructoselysine
Molecular Weight	308.33
Formula	C12H24N2O7
CAS No.	21291-40-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11. 2. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5.

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Keywords

Fructosyl-lysine 21291-40-7 Others Fructoselysine Fructosyl lysine Fructosyllysine inhibitor inhibit

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