store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells by increasing the dGTP levels.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | In stock | $ 59.00 |
Description | Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells by increasing the dGTP levels. |
Targets&IC50 | PNP (human):1.19 nM, PNP (monkey):0.66 nM, PNP (mouse):0.48 nM, PNP (rat):1.24 nM, PNP (dog):1.57 nM |
In vitro | Forodesine (10-30?μM; 24 and 48 hours; RPMI-8226, MOLT-4, and 5T33MM cells) has no effect on the MM cells at 24 hours, while it could decrease the percentage of living cells in the MOLT-4 cells with 40%. Forodesine (10-30?μM; 24 and 48 hours; RPMI-8226, MOLT-4, and 5T33MM cells) treatment is partially inhibition of proliferation [1]. Forodesine inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50s < 0.1-0.38 μM), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM) [2]. |
In vivo | Forodesine has excellent oral bioavailability (63%) in mice. Forodesine(single dose of 10 mg/kg; in mice ) treatment, elevates dGuo to approximately 5 μM. Forodesine is effective in prolonging the life span 2-fold or more, in the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model [2]. |
Synonyms | BCX-1777, Immucillin-H |
Molecular Weight | 266.25 |
Formula | C11H14N4O4 |
CAS No. | 209799-67-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Forodesine 209799-67-7 Others BCX 1777 BCX-1777 BCX1777 Immucillin-H inhibitor inhibit