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Folinic Acid Calcium Salt Pentahydrate

Folinic Acid Calcium Salt Pentahydrate
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Purity:100%
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Folinic Acid Calcium Salt Pentahydrate

Catalog No. T0148LCas No. 6035-45-6
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
100 mg$41In Stock
500 mg$84In Stock
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Product Introduction

Bioactivity
Description
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
In vitro
Administering either 100 or 200 mg/kg of Leucovorin bi-daily for 4-6 days reduced the concentration of RTX in the liver by 2-4 fold compared to the control group in mice. Post severe weight loss and diarrhea, dosing mice with 200 mg/kg of Leucovorin twice daily for 5-7 days prevented further weight decline and initiated early recovery. Concurrent use of Leucovorin/5-FU with a gastric and colorectal cancer vaccine (200 mg/ml) enhanced the therapeutic effect on the growth of DHDK12 tumors in vivo.
In vivo
In both tumor and normal tissues, Leucovorin acts as a reduced folate cofactor, competitively transporting and promoting polyglutamation with RTX, thereby serving as a potential rescue agent. In CCRF-CEM cells, Leucovorin enhances the toxicity of trimethoprim/fluorouracil but does not increase the toxicity of methotrexate/fluorouracil. It also enhances the cytotoxicity of RTX and reverses growth inhibition. Exposure to 20 mM Leucovorin in 11 human colon cancer cell lines results in increased cytotoxicity. The augmentation of Leucovorin slows the reduction of folate levels in tissues, thus enhancing the inhibitory effect of thymidylate synthase on murine colonic tumors.
AliasFolinic acid, Leucovorin Calcium Pentahydrate, Leucovorin calcium salt pentahydrate
Chemical Properties
Molecular Weight601.58
FormulaC20H21CaN7O7·5H2O
Cas No.6035-45-6
Storage & Solubility Information
Storagekeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 10 mM
DMSO: Insoluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
10 mM0.1662 mL0.8311 mL1.6623 mL8.3114 mL
20 mM0.0831 mL0.4156 mL0.8311 mL4.1557 mL
50 mM0.0332 mL0.1662 mL0.3325 mL1.6623 mL
100 mM0.0166 mL0.0831 mL0.1662 mL0.8311 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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