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Ezetimibe ketone

Catalog No. T11251 CAS 191330-56-0

Synonyms: EZM-K

Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally, Ezetimibe ketone (EZM-K) represents a phase-I metabolite of Ezetimibe.

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Ezetimibe ketone, CAS 191330-56-0

Pack Size	Availability	Price/USD
2 mg	5 days	$ 154.00
5 mg	5 days	$ 263.00
10 mg	5 days	$ 422.00
25 mg	5 days	$ 872.00
50 mg	5 days	$ 1,390.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	EZM-K
Molecular Weight	407.41
Formula	C24H19F2NO3
CAS No.	191330-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. 2. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. 3. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ezetimibe ketone 191330-56-0 Immunology/Inflammation Membrane transporter/Ion channel Nrf2 NPC1L1 EZM-K inhibitor inhibit

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