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Elvitegravir

Catalog No. T2332   CAS 697761-98-1
Synonyms: GS-9137, EVG, D06677, JTK-303

Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Elvitegravir Chemical Structure
Elvitegravir, CAS 697761-98-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 79.00
25 mg In stock $ 155.00
50 mg In stock $ 298.00
100 mg In stock $ 486.00
1 mL * 10 mM (in DMSO) In stock $ 47.00
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Purity: 99.73%
Purity: 99.57%
Purity: 98.35%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer.
Targets&IC50 HIV-2 EHO:2.8 nM, HIV-1 IIIB:0.7 nM, HIV-2 ROD:1.4 nM
Cell Research Elvitegravir (EVG) is prepared in DMSO and stored, and then diluted with appropriate medium before use[1]. MT-2 cells (2×105 cells) are infected with HIV-1 IIIB and then cultured in the presence of 0.5 nM or 0.1 nM Elvitegravir. Cultures are incubated at 37°C until an extensive cytopathic effect (CPE) is observed, and the culture supernatant is then harvested for further passage in fresh MT-2 cells. The concentration of Elvitegravir is increased when a significant CPE is observed. At the indicated passages, proviral DNA is extracted from infected MT-2 cells and then subjected to PCR, followed by direct population-based sequencing. Susceptibility to Elvitegravir at the indicated passages is determined using the MAGI assay or p24 production[1].
Synonyms GS-9137, EVG, D06677, JTK-303
Molecular Weight 447.88
Formula C23H23ClFNO5
CAS No. 697761-98-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL (183.1 mM)

Ethanol: 33 mg/mL (73.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Shimura K, et al. J Virol. 2008, 82(2), 764-774. 2. Lampiris HW. Expert Rev Anti Infect Ther. 2012, 10(1), 13-20.

TargetMolCitations

1. Kaduk J A, Gates-Rector S, Blanton T N.Crystal structure of elvitegravir Form II, C23H23ClFNO5.Powder Diffraction.2023: 1-11.

Related compound libraries

This product is contained In the following compound libraries:
Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Inhibitor Library Fluorochemical Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved Drug Library Bioactive Compounds Library Max Anti-Viral Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library

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Keywords

Elvitegravir 697761-98-1 Microbiology/Virology Proteases/Proteasome HIV Protease inhibit HIV-1IIIB HIV-2EHO HIV GS 9137 JTK 303 HIV Integrase GS-9137 cDNA D-06677 EVG Inhibitor GS9137 D06677 JTK-303 HIV-2ROD JTK303 D 06677 Human immunodeficiency virus inhibitor

 

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