Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 79.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 298.00 | |
100 mg | In stock | $ 486.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 47.00 |
Description | Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer. |
Targets&IC50 | HIV-2 EHO:2.8 nM, HIV-1 IIIB:0.7 nM, HIV-2 ROD:1.4 nM |
Cell Research | Elvitegravir (EVG) is prepared in DMSO and stored, and then diluted with appropriate medium before use[1]. MT-2 cells (2×105 cells) are infected with HIV-1 IIIB and then cultured in the presence of 0.5 nM or 0.1 nM Elvitegravir. Cultures are incubated at 37°C until an extensive cytopathic effect (CPE) is observed, and the culture supernatant is then harvested for further passage in fresh MT-2 cells. The concentration of Elvitegravir is increased when a significant CPE is observed. At the indicated passages, proviral DNA is extracted from infected MT-2 cells and then subjected to PCR, followed by direct population-based sequencing. Susceptibility to Elvitegravir at the indicated passages is determined using the MAGI assay or p24 production[1]. |
Synonyms | GS-9137, EVG, D06677, JTK-303 |
Molecular Weight | 447.88 |
Formula | C23H23ClFNO5 |
CAS No. | 697761-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 82 mg/mL (183.1 mM)
Ethanol: 33 mg/mL (73.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Elvitegravir 697761-98-1 Microbiology/Virology Proteases/Proteasome HIV Protease inhibit HIV-1IIIB HIV-2EHO HIV GS 9137 JTK 303 HIV Integrase GS-9137 cDNA D-06677 EVG Inhibitor GS9137 D06677 JTK-303 HIV-2ROD JTK303 D 06677 Human immunodeficiency virus inhibitor