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Diethylcarbamazine

Catalog No. T20825   CAS 90-89-1
Synonyms: Diaethylcarbamazinum, Bitirazine, AI3-19612, RP3799, RP-3799, RP 3799,

Diethylcarbamazine, an anthelmintic, is used primarily as the citrate in the treatment of filariasis, particularly infestations with Loa loa or Wucheria bancrofti.

Diethylcarbamazine, CAS 90-89-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diethylcarbamazine, an anthelmintic, is used primarily as the citrate in the treatment of filariasis, particularly infestations with Loa loa or Wucheria bancrofti.
Synonyms Diaethylcarbamazinum , Bitirazine , AI3-19612 , RP3799 , RP-3799 , RP 3799 ,
Purity
Molecular Weight 199.29
Formula C10H21N3O
CAS No. 90-89-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Abdel-Latif M, Sakran T, El-Shahawi G, El-Fayoumi H, El-Mallah AM. Effect of diethylcarbamazine citrate and Setaria equina excretory-secretory material on rat hepatocellular carcinoma. Arch Immunol Ther Exp (Warsz). 2014 Dec;62(6):511-20. doi: 10.1007/s00005-014-0292-z. Epub 2014 May 31. PubMed PMID: 24879096. 2. Siram K, Chellan VR, Natarajan T, Krishnamoorthy B, Mohamed Ebrahim HR, Karanam V, Muthuswamy SS, Ranganathan HP. Solid lipid nanoparticles of diethylcarbamazine citrate for enhanced delivery to the lymphatics: in vitro and in vivo evaluation. Expert Opin Drug Deliv. 2014 Sep;11(9):1351-65. doi: 10.1517/17425247.2014.915310. Epub 2014 May 21. PubMed PMID: 24847779. 3. Awadzi K, Opoku NO, Attah SK, Lazdins-Helds JK, Kuesel AC. Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch. Parasit Vectors. 2015 Oct 9;8:515. doi: 10.1186/s13071-015-1122-9. PubMed PMID: 26452723; PubMed Central PMCID: PMC4598973. 4. Schmidt MS, King CL, Thomsen EK, Siba PM, Sanuku N, Fleckenstein L. Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies. J Pharm Biomed Anal. 2014 Sep;98:307-10. doi: 10.1016/j.jpba.2014.05.016. Epub 2014 May 22. PubMed PMID: 24975211.

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