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Decoyinine

Catalog No. T15091 CAS 2004-04-8

Synonyms: Decynylene, Angustmycin A

Decoyinine (Decynylene), a selective inhibitor of GMP synthase, is a novel potential microbial insecticide, a secondary metabolite produced by Streptomyces hygroscopicus.Decoyinine induces resistance in rice to the small brown ladybug Laodelphax striatellus.

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Decoyinine, CAS 2004-04-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
5 mg	In stock	$ 279.00
10 mg	In stock	$ 558.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 239.00

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Purity: 99.12%

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Description	Decoyinine (Decynylene), a selective inhibitor of GMP synthase, is a novel potential microbial insecticide, a secondary metabolite produced by Streptomyces hygroscopicus.Decoyinine induces resistance in rice to the small brown ladybug Laodelphax striatellus.
In vitro	Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the gra-10 mutation. Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on B. subtilis WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity.[2]
In vivo	Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations.[1]

Synonyms	Decynylene, Angustmycin A
Molecular Weight	279.25
Formula	C11H13N5O4
CAS No.	2004-04-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (161.1 mM ), Sonication and heating to 60℃ are recommended.

References and Literature

1. A Bianchi-Smiraglia, et al. Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity. Cell Death Differ. 2015;22(11): 1858–1864. 2. W L Nicholson, et al. Effect of Decoyinine on the regulation of alpha-amylase synthesis in Bacillus subtilis. J Bacteriol. 1987;169(12): 5867–5869. 3. Shah AZ, et al. Decoyinine Induced Resistance in Rice against Small Brown Planthopper Laodelphax striatellus. Insects. 2022;13(1):104.

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This product is contained In the following compound libraries：

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Keywords

Decoyinine 2004-04-8 Decynylene Angustmycin A inhibitor inhibit

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