Powder: -20°C for 3 years | In solvent: -80°C for 1 year
D-Cl-amidine is an effective and highly selective PAD1 inhibitor. D-Cl-amidine has a good correlation and no obvious toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | D-Cl-amidine is an effective and highly selective PAD1 inhibitor. D-Cl-amidine has a good correlation and no obvious toxicity. |
In vitro | D-D-Cl-amidine (200-400μM) can effectively reduce the cell viability of MDA-MB-231 cells . D-Cl-amidine increased the activity of caspase 3, indicating that inhibition of PAD1 resulted in increased apoptosis. |
In vivo | D-Cl-amidine administered intravenously at a dose of 2.5 mg / kg was still detected at a concentration of approximately 21 nM in serum after 2 h and 4 h at a concentration of approximately 10 nM. Intraperitoneal injection of D-Cl-amidine at a dose of 10 mg / kg was still observed at a concentration of approximately 10 nM at 4 h. |
Molecular Weight | 310.78 |
Formula | C14H19ClN4O2 |
CAS No. | 1404060-15-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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D-Cl-amidine 1404060-15-6 Others D Cl amidine DClamidine inhibitor inhibit