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Chiglitazar

Catalog No. T14948 CAS 743438-45-1

Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).

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Chiglitazar, CAS 743438-45-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 954.00
50 mg	6-8 weeks	$ 1,240.00
100 mg	6-8 weeks	$ 1,990.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
Targets&IC50	PPARγ:0.08 μM （EC50）, PPARα:1.8 μM （EC50）, PPARδ:1.7 μM （EC50）
In vitro	Chiglitazar shows weaker PPARγ activating activity than rosiglitazone, but stronger than pioglitazone. In terms of PPARα activation, Chiglitazar shows a more potent activity than rosiglitazone, pioglitazone, or WY14643 which is a selective PPARα agonist [1].
In vivo	Plasma glucose levels in the MSG rats treated with Chiglitazar or rosiglitazone are significantly reduced compared with the control group treated with the vehicle, after insulin injection. Fasting PI levels are lower in animals treated with Chiglitazar and rosiglitazone than control. Chiglitazar ameliorates the HOMA indices. For IPGTT, at the 30?min after glucose loading, the glucose values in the 5 and 10?mg/kg Chiglitazar and rosiglitazone-treatment groups are significantly lower than those in the vehicle treatment group [1].

Molecular Weight	572.62
Formula	C36H29FN2O4
CAS No.	743438-45-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Li PP, et al. The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol. 2006 Jul;148(5):610-8. 2. He BK, et al. In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. PPAR Res. 2012;2012:546548.

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Keywords

Chiglitazar 743438-45-1 DNA Damage/DNA Repair Metabolism PPAR inhibitor inhibit

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