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Boc-NH-PEG8-CH2CH2NH2

Name: Boc-NH-PEG8-CH2CH2NH2
Brand: TargetMol
SKU: T17684
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17684Cas No. 1052207-59-6

Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker utilized in PROTAC synthesis.

Boc-NH-PEG8-CH2CH2NH2

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Purity: 98.75%

Catalog No. T17684Cas No. 1052207-59-6

Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker utilized in PROTAC synthesis.

Pack Size	Price	Availability	Quantity
25 mg	$29	In Stock

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Batch Information

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Purity:98.75%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker utilized in PROTAC synthesis.
In vitro	PROTACs consist of two ligands joined by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	512.63
Formula	C₂₃H₄₈N₂O₁₀
Cas No.	1052207-59-6
Smiles	O(CCOCCOCCOCCOCCOCCOCCOCCN)CCNC(OC(C)(C)C)=O
Relative Density.	1.078 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (195.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9507 mL	9.7536 mL	19.5072 mL	97.5362 mL
5 mM	0.3901 mL	1.9507 mL	3.9014 mL	19.5072 mL
10 mM	0.1951 mL	0.9754 mL	1.9507 mL	9.7536 mL
20 mM	0.0975 mL	0.4877 mL	0.9754 mL	4.8768 mL
50 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9507 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc