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Bay 41-4109 (less active enantiomer)
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Catalog No. T10480Cas No. 476617-51-3
Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.
Bay 41-4109 (less active enantiomer)
😃Good
Catalog No. T10480Cas No. 476617-51-3
Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,220 | 6-8 weeks | |
| 50 mg | $2,680 | 6-8 weeks | |
| 100 mg | $3,200 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer. |
| Targets&IC50 | HBV:53 nM |
| In vivo | BAY 41-4109 exhibits dose-dependent reductions in viral DNA levels in both the liver and plasma, demonstrating effectiveness commensurate with 3TC. It also diminishes the hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic analyses reveal swift absorption, a 30% bioavailability in mice, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs [1]. Furthermore, BAY41-4109 disrupts in vivo virus production through a mechanism that interacts with the viral capsid [2]. |
| Molecular Weight | 395.76 |
| Formula | C18H13ClF3N3O2 |
| Cas No. | 476617-51-3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 37 mg/mL (93.49 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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