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Bay 41-4109 (less active enantiomer)

Bay 41-4109 (less active enantiomer)
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Bay 41-4109 (less active enantiomer)

Catalog No. T10480Cas No. 476617-51-3
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$293Backorder
10 mg$443Backorder
50 mg$1,323Backorder
100 mg$1,850Backorder
200 mgInquiryBackorder
500 mgInquiryBackorder
1 mL x 10 mM (in DMSO)$256Backorder
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Product Introduction

Bioactivity
Description
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
In vivo
BAY 41-4109 exhibits dose-dependent reductions in viral DNA levels in both the liver and plasma, demonstrating effectiveness commensurate with 3TC. It also diminishes the hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic analyses reveal swift absorption, a 30% bioavailability in mice, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs [1]. Furthermore, BAY41-4109 disrupts in vivo virus production through a mechanism that interacts with the viral capsid [2].
Chemical Properties
Molecular Weight395.76
FormulaC18H13ClF3N3O2
Cas No.476617-51-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 37 mg/mL (93.49 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5268 mL12.6339 mL25.2678 mL126.3392 mL
5 mM0.5054 mL2.5268 mL5.0536 mL25.2678 mL
10 mM0.2527 mL1.2634 mL2.5268 mL12.6339 mL
20 mM0.1263 mL0.6317 mL1.2634 mL6.3170 mL
50 mM0.0505 mL0.2527 mL0.5054 mL2.5268 mL

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For example, your dosage is 10 mg/kg, each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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2 Enter the in vivo formulation:
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