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Bay 41-4109 (less active enantiomer)

Catalog No. T10480 CAS 476617-51-3

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).

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Bay 41-4109 (less active enantiomer), CAS 476617-51-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
Targets&IC50	HBV, Bay 41-4109:53 nM
In vitro	BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers [2]. In HepG2.2.15 cells, BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level (IC50s: 32.6 and 132 nM). HBV DNA and HBcAg are inhibited in a dose-dependent manner [3].
In vivo	BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces the hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30%, and dose-proportional plasma concentrations, about 60% in rats and dogs [1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid [2].

Molecular Weight	395.76
Formula	C18H13ClF3N3O2
CAS No.	476617-51-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 37 mg/mL (93.49 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. 2. Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. 3. Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67.

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Keywords

Bay 41-4109 (less active enantiomer) 476617-51-3 微生物学 HBV Bay 41 4109 (less active enantiomer) Bay 414109 (less active enantiomer) Inhibitor inhibitor inhibit

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