Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
Description | Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM). |
Targets&IC50 | HBV, Bay 41-4109:53 nM |
In vitro | BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers [2]. In HepG2.2.15 cells, BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level (IC50s: 32.6 and 132 nM). HBV DNA and HBcAg are inhibited in a dose-dependent manner [3]. |
In vivo | BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces the hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30%, and dose-proportional plasma concentrations, about 60% in rats and dogs [1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid [2]. |
Molecular Weight | 395.76 |
Formula | C18H13ClF3N3O2 |
CAS No. | 476617-51-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 37 mg/mL (93.49 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Bay 41-4109 (less active enantiomer) 476617-51-3 微生物学 HBV Bay 41 4109 (less active enantiomer) Bay 414109 (less active enantiomer) Inhibitor inhibitor inhibit