Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 138.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 347.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 161.00 |
Description | Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT). |
In vitro | One hundred-ninety flavonoids and 75 alkaloids were studied for their inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT) by using (rA) n-p(dT) <12-18> or (rC) n-p(dG) <12-18> as a template-primer. Of the flavonoids tested, 6-hydroxyluteolin (50), pedalitin (52), 6-hydroxykaempferol (109) and quercetagetin (129), were the most potent inhibitors with IC50?:10 μM. Five other flavonoids, baicalein (19), Baicalin methyl ester (23), scutellarein (33), myricetin (126) and gossypetin (130), gave IC50 between 35 and 200 μM. The kinetic studies on 50, 126 and 130 gave the inhibitory constants ki of 10, 94 and 90 μM, respectively, with respect to the substrate and 5, 200 and 100 μM, respectively, with respect to the template-primer. Structurally different alkaloids such as isoquinoline, indol, steroidal, quinolizidine, pyrrolizidine, pyridine and imidazole alkaloids were also investigated for the activity and berberine type alkaloids were shown to have a strong inhibitory activity. |
Source |
Molecular Weight | 460.39 |
Formula | C22H20O11 |
CAS No. | 82475-03-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (97.74 mM)
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Baicalin methyl ester 82475-03-4 Microbiology/Virology Anti-infection Inhibitor inhibit inhibitor