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Baicalin methyl ester

Catalog No. TN1427   CAS 82475-03-4

Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).

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Baicalin methyl ester Chemical Structure
Baicalin methyl ester, CAS 82475-03-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 138.00
10 mg In stock $ 198.00
25 mg In stock $ 347.00
1 mL * 10 mM (in DMSO) In stock $ 161.00
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Purity: 95.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Baicalin methyl ester shows inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT).
In vitro One hundred-ninety flavonoids and 75 alkaloids were studied for their inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT) by using (rA) n-p(dT) <12-18> or (rC) n-p(dG) <12-18> as a template-primer. Of the flavonoids tested, 6-hydroxyluteolin (50), pedalitin (52), 6-hydroxykaempferol (109) and quercetagetin (129), were the most potent inhibitors with IC50?:10 μM. Five other flavonoids, baicalein (19), Baicalin methyl ester (23), scutellarein (33), myricetin (126) and gossypetin (130), gave IC50 between 35 and 200 μM. The kinetic studies on 50, 126 and 130 gave the inhibitory constants ki of 10, 94 and 90 μM, respectively, with respect to the substrate and 5, 200 and 100 μM, respectively, with respect to the template-primer. Structurally different alkaloids such as isoquinoline, indol, steroidal, quinolizidine, pyrrolizidine, pyridine and imidazole alkaloids were also investigated for the activity and berberine type alkaloids were shown to have a strong inhibitory activity.
Source
Molecular Weight 460.39
Formula C22H20O11
CAS No. 82475-03-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (97.74 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Effects of Flavonoids and Alkaloids on Reverse TranscriptaseJapanese Journal of Pharmacognosy , 1991 , 45 (3) :240-254.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Infection Compound Library Flavonoid Natural Product Library Bioactive Compounds Library Max Natural Product Library Anti-Viral Compound Library Natural Product Library for HTS Anti-infective Natural Product Library Bioactive Compound Library Inhibitor Library RO5 Drug-like Natural Product Library

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Keywords

Baicalin methyl ester 82475-03-4 Microbiology/Virology Anti-infection Inhibitor inhibit inhibitor

 

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