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BMS202 hydrochloride (1675203-84-5(free base))

Catalog No. T4696 CAS T4696

Synonyms: PD-1/PD-L1 inhibitor 2 hydrochloride

PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

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BMS202 hydrochloride (1675203-84-5(free base)), CAS T4696

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
Targets&IC50	PD-1/PD-L1:18 nM

Synonyms	PD-1/PD-L1 inhibitor 2 hydrochloride
Molecular Weight	455.97
Formula	C25H30ClN3O3
CAS No.	T4696

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL(71.51 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zak KM, Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).Oncotarget. 2016 May 24;7(21):30323-35. 2. Pardoll DM.The blockade of immune checkpoints in cancer immunotherapy.Nat Rev Cancer. 2012 Mar 22;12(4):252-64.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-COVID-19 Compound Library Anti-Breast Cancer Compound Library Apoptosis Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

AUNP-12 acetate Pembrolizumab Nivolumab Avelumab Atezolizumab PD-1/PD-L1-IN-10 PD-1/PD-L1-IN-NP19 Spartalizumab (anti-PD-1)

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS202 hydrochloride (1675203-84-5(free base)) T4696 凋亡免疫与炎症细胞周期 PD-1/PD-L1 PD-1/PD-L1 inhibitor 2 hydrochloride BMS-202 hydrochloride (1675203-84-5(free base)) BMS202 hydrochloride (1675203 84 5(free base)) BMS202 hydrochloride (1675203845(free base)) Inhibitor inhibitor inhibit

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