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BMS202 hydrochloride (1675203-84-5(free base))

Catalog No. T4696   CAS 2089334-95-0
Synonyms: PD-1/PD-L1 inhibitor 2 hydrochloride

BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

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BMS202 hydrochloride (1675203-84-5(free base)) Chemical Structure
BMS202 hydrochloride (1675203-84-5(free base)), CAS 2089334-95-0
Pack Size Availability Price/USD Quantity
1 mg Inquiry $ 47.00
2 mg Inquiry $ 57.00
5 mg Inquiry $ 102.00
10 mg Inquiry $ 163.00
25 mg Inquiry $ 323.00
50 mg Inquiry $ 577.00
100 mg Inquiry $ 826.00
1 mL * 10 mM (in DMSO) In stock $ 102.00
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Purity: 99.47%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
Targets&IC50 PD-1/PD-L1:18 nM
Synonyms PD-1/PD-L1 inhibitor 2 hydrochloride
Molecular Weight 455.97
Formula C25H30ClN3O3
CAS No. 2089334-95-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL(71.51 mM)

TargetMolReferences and Literature

1. Zak KM, Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).Oncotarget. 2016 May 24;7(21):30323-35. 2. Pardoll DM.The blockade of immune checkpoints in cancer immunotherapy.Nat Rev Cancer. 2012 Mar 22;12(4):252-64.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Immunology/Inflammation Compound Library Immuno-Oncology Compound Library NO PAINS Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library Apoptosis Compound Library Anti-COVID-19 Compound Library Bioactive Compound Library Anti-Breast Cancer Compound Library

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Related compounds with same targets
Fraxinellone Spartalizumab (anti-PD-1) ASC-69 BMS-1001 AUNP-12 acetate Sintilimab (anti-PD-1) PD-1-IN-22 Danburstotug

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Keywords

BMS202 hydrochloride (1675203-84-5(free base)) 2089334-95-0 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 PD-1/PD-L1 inhibitor 2 hydrochloride BMS-202 hydrochloride (1675203-84-5(free base)) BMS202 hydrochloride (1675203 84 5(free base)) PD-1/PD-L1 inhibitor 2 Hydrochloride BMS202 hydrochloride (1675203845(free base)) inhibitor inhibit

 

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