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BMS-199264 hydrochloride

Name: BMS-199264 hydrochloride
Brand: TargetMol
SKU: T26843
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26843Cas No. 186180-83-6

Alias BMS199264 hydrochloride

BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.

BMS-199264 hydrochloride

🥰Excellent

Purity: 99.86%

Catalog No. T26843Alias BMS199264 hydrochlorideCas No. 186180-83-6

Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$293	In Stock
10 mg	$469	In Stock
25 mg	$939	In Stock
50 mg	$1,520	In Stock
100 mg	$2,430	In Stock
200 mg	$3,290	In Stock

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Purity:99.86%

ee:100%

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COA CSFC HNMR IC LCMS ORP

Product Introduction

Bioactivity

Description	BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.
Targets&IC50	Mitochondrial F₁F₀ ATP synthase:0.5 μM
In vitro	BMS-199264 hydrochloride selectively inhibits the hydrolase activity of mitochondrial F₁F₀ ATP synthase in vitro (IC₅₀ = 0.5 μM), without significant effects on its synthase activity or ATP-sensitive potassium channels. [1]
In vivo	BMS-199264 hydrochloride exhibited in an isolated rat heart ischemia model: hearts were pretreated with 3 μM BMS-199264 hydrochloride for 10 minutes before global ischemia. After 15 minutes of ischemia, mitochondrial F₁F₀ ATP synthase activity was measured, showing that BMS-199264 hydrochloride selectively inhibited hydrolase activity without affecting synthase function.[1]
Synonyms	BMS199264 hydrochloride

Chemical Properties

Molecular Weight	567.53
Formula	C₂₆H₃₂Cl₂N₄O₄S
Cas No.	186180-83-6
Smiles	N(CC=1NC=CN1)([C@@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(S(=O)(=O)N4CCCCC4)C3)C5=CC=C(Cl)C=C5.Cl
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (140.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7620 mL	8.8101 mL	17.6202 mL	88.1011 mL
5 mM	0.3524 mL	1.7620 mL	3.5240 mL	17.6202 mL
10 mM	0.1762 mL	0.8810 mL	1.7620 mL	8.8101 mL
20 mM	0.0881 mL	0.4405 mL	0.8810 mL	4.4051 mL
50 mM	0.0352 mL	0.1762 mL	0.3524 mL	1.7620 mL
100 mM	0.0176 mL	0.0881 mL	0.1762 mL	0.8810 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc