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Azelaic acid

Catalog No. T0926 CAS 123-99-9

Synonyms: Finacea, Azelex, Nonanedioic acid, Anchoic acid

Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.

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Azelaic acid, CAS 123-99-9

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.89%

Biological Description

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Storage & Solubility Information

Description	Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
In vitro	AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].
In vivo	Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].
Cell Research	B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader. (Only for Reference)
Source	Natural Products > Ericaceae > Rhododendron

Synonyms	Finacea, Azelex, Nonanedioic acid, Anchoic acid
Molecular Weight	188.22
Formula	C9H16O4
CAS No.	123-99-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 35 mg/mL (186 mM)

DMSO: 35 mg/mL (186 mM)

H2O: 34 mg/mL (180.6 mM)

References and Literature

1. Litvinov D, et al. Atherosclerosis. 2010, 209(2):449-54. 2. Yu JS, et al. J Biomed Sci. 2010, 17 Suppl 1:S45.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Human Endogenous Metabolite Library Tobacco Monomer Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Marine Natural Product Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Miao medicine Compound Library

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Keywords

Azelaic acid 123-99-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Others Endogenous Metabolite DNA/RNA Synthesis Finacea Azelex inhibit Nonanedioic acid Inhibitor Anchoic acid inhibitor

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