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Aplodan (Synonyms: Nergize, creatinol-O-phosphate, Creatinolfosfate, Creatinol Phosphate, Creatinolfosfate)
Catalog No. T20843 Copy Product Info
Purity: 99.87%
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Aplodan (creatinol-O-phosphate) exhibits antiischemic and antiarrhythmic capacity and protective action on the cell membrane. Aplodan can be used in research on the ischemic heart or ischemic heart disease with persistent ventricular premature beats.
Aplodan
Copy Product Info😃Good
Catalog No. T20843
Synonyms Nergize, creatinol-O-phosphate, Creatinolfosfate, Creatinol Phosphate, Creatinolfosfate
Aplodan (creatinol-O-phosphate) exhibits antiischemic and antiarrhythmic capacity and protective action on the cell membrane. Aplodan can be used in research on the ischemic heart or ischemic heart disease with persistent ventricular premature beats.
Cas No. 6903-79-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 mg | $39 | In Stock | In Stock | |
| 500 mg | $100 | In Stock | In Stock | |
| 1 g | $147 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.87%
Appearance:Solid
Color:White
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Product Introduction
Aplodan AI Summary
Aplodan exhibits antiviral activity against SARS-CoV-2 through multiple mechanisms. It inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 cells (14.56% inhibition at 10 µM after 48 hours) and VERO-6 cells (with inhibition rates recorded at 0.14% and -0.1% under similar conditions). The compound targets the SARS-CoV-2 3CL-Pro protease, showing inhibition percentages of 30.77% and 8.162% at 20 µM. However, its efficacy as measured in HRCE cells is relatively low, with a hit score of 0.1189. Additionally, Aplodan demonstrates a 20.66% inhibition in an enzymatic assay of human HDAC6 using a commercial peptide substrate, indicating its potential multi-faceted role in antiviral response and enzyme inhibition..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aplodan (creatinol-O-phosphate) exhibits antiischemic and antiarrhythmic capacity and protective action on the cell membrane. Aplodan can be used in research on the ischemic heart or ischemic heart disease with persistent ventricular premature beats. |
| Synonyms | Nergize, creatinol-O-phosphate, Creatinolfosfate, Creatinol Phosphate, Creatinolfosfate |
| Molecular Weight | 197.13 |
| Formula | C4H12N3O4P |
| Cas No. | 6903-79-3 |
| Smiles | CN(CCOP(O)(O)=O)C(N)=N |
| Relative Density. | 1.65 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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