Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 33.00 | |
5 mg | 5 days | $ 51.00 |
Description | Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2]. |
In vitro | PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 337.32 |
Formula | C13H23NO9 |
CAS No. | 174362-95-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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