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Alclometasone dipropionate

Catalog No. T21361 CAS 66734-13-2

Synonyms: Vaderm, Sch 22219, Aclovate, Delonal

Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Alclometasone dipropionate Chemical Structure

Alclometasone dipropionate, CAS 66734-13-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83.00
2 mg	In stock	$ 125.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 296.00
25 mg	In stock	$ 533.00
50 mg	In stock	$ 795.00
100 mg	In stock	$ 1,193.00

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Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.
In vitro	The suppressive effect of tacrolimus on cytokine production was stronger than that of alclometasone dipropionate and equal to or stronger than that of betamethason valerate. The effective dose of tacrolimus (IC50, 0.02-0.11 ng/ml) is almost the same as for Th1 and Th2 cytokines, and 1 ng/ml of tacrolimus suppressed all cytokines completely[1].
In vivo	In Lewis rats with tuberculin-induced delayed-type hypersensitivity reaction, alclometasone dipropionate (0.1% (20μL, administered once to the ear) partially inhibited the increase in dye leakage, indicating its impact on hypersensitivity reactions induced by tuberculin and ovalbumin [2].

Synonyms	Vaderm, Sch 22219, Aclovate, Delonal
Molecular Weight	521.04
Formula	C28H37ClO7
CAS No.	66734-13-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 5 mg/mL (9.60 mM), Sonication is recommended.

References and Literature

1. Sakuma S, et al. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. 2. Sengoku T, et al. Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur J Pharmacol. 1999 Aug 27;379(2-3):183-9. 3. Yamamoto Y, Fukami T, Koide T, Suzuki T, Hiyama Y, Tomono K. Pharmaceutical evaluation of steroidal ointments by ATR-IR chemical imaging: distribution of active and inactive pharmaceutical ingredients. Int J Pharm. 2012 Apr 15;426(1-2):54-60. doi: 10.1016/j.ijpharm.2012.01.017. Epub 2012 Jan 20. PubMed PMID: 22286017. 4. Isaksson M. Corticosteroid contact allergy--the importance of late readings and testing with corticosteroids used by the patients. Contact Dermatitis. 2007 Jan;56(1):56-7. PubMed PMID: 17177720.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alclometasone dipropionate 66734-13-2 Others Vaderm Sch 22219 Aclovate Delonal Almeta Alclometasone inhibitor inhibit

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