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Adrenochrome

Catalog No. T20094   CAS 54-06-8
Synonyms: Adraxone

Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associated with cardiotoxicity and can be used to determine superoxide dismutase activity. Adrenochrome is a potential psychotropic drug for the study of nervous system diseases.

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Adrenochrome Chemical Structure
Adrenochrome, CAS 54-06-8
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Purity: 98.72%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associated with cardiotoxicity and can be used to determine superoxide dismutase activity. Adrenochrome is a potential psychotropic drug for the study of nervous system diseases.
In vitro Microsomal calcium binding, calcium uptake, and Ca2+-stimulated Mg2+-dependent ATPase activities are reduced in the presence of Adrenochrome. The inhibitory impact of Adrenochrome on microsomal calcium uptake activity of the isolated membrane remains unaffected by various factors, including pH (ranging from 6.0 to 8.0), calcium concentrations (ranging from 10 to 200 μM), protein concentration (ranging from 0.02 to 0.10 mg/mL), temperature (ranging from 25 to 37 degrees C), and incubation time (ranging from 2 to 30 minutes). [1]
In vivo In isolated rat hearts, the administration of Adrenochrome at concentrations ranging from 1 to 1000 ng/mL leads to a dose- and time-dependent elevation in coronary pressure. Moreover, the extent of constriction induced by Adrenochrome is influenced by the concentration of CaCl2 in the perfusion medium. [2]
Synonyms Adraxone
Molecular Weight 179.17
Formula C9H9NO3
CAS No. 54-06-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (502.3 mM), sonification is recommended.

TargetMolReferences and Literature

1. Takeo S, et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980;214(3):688-693. 2. Karmazyn M, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981;219(1):225-230. 3. Ueda K, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45(10):619-624. 4. Cassagnes LE, et al. Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. Free Radic Biol Med. 2018;120:56-61. 5. Prasad A, et al. Real-time monitoring of superoxide anion radical generation in response to wounding: electrochemical study. PeerJ. 2017;5:3050.

Related compound libraries

This product is contained In the following compound libraries:
Antioxidant Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Adrenochrome 54-06-8 oxidation-reduction Antioxidant Adraxone inhibitor inhibit

 

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