Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugate for antibody-drug conjugates (ADCs), featuring a natural bis-intercalator, SW-163D, attached through an AcLysValCitPABC-DMAE linker[1].
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Description | AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugate for antibody-drug conjugates (ADCs), featuring a natural bis-intercalator, SW-163D, attached through an AcLysValCitPABC-DMAE linker[1]. |
In vitro | SW-163D, a cyclodepsipeptide antibiotic sourced from Streptomyces sp., demonstrates antitumor properties. PF06888667, characterized as a potent, stable, and effective Antibody-Drug Conjugate (ADC), comprises SW-163D linked to an engineered variant of trastuzumab, an anti-Her2 monoclonal antibody (mAb), through an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker. This conjugation is facilitated by transglutaminase. |
Molecular Weight | 1817.07 |
Formula | C85H113N19O22S2 |
CAS No. | 2411007-69-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AcLysValCit-PABC-DMAE-SW-163D 2411007-69-5 Others AcLysValCitPABCDMAESW163D AcLysValCit PABC DMAE SW 163D inhibitor inhibit