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Abacavir hydroxyacetate

Name: Abacavir hydroxyacetate
Brand: TargetMol
SKU: T1267L
Rating: 4.5 (1 reviews)

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Catalog No. T1267LCas No. 1446418-48-9

Alias Abacavirhydroxyacetate

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.

Abacavir hydroxyacetate

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Purity: 98.29%

Catalog No. T1267LAlias AbacavirhydroxyacetateCas No. 1446418-48-9

Pack Size	Price	Availability	Quantity
2 mg	Inquiry	In Stock

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Purity:98.29%

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COA HNMR LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.
In vivo	In 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue, Abacavir hydroxyacetate (10 and 20 mg/kg; oral gavage; 10-20 mg/kg once) decreases the concentration of PRINS and IL-20, and reduces the lesion area of the skin, showing a better effect than methotrexate in controlling psoriasis[1].
Alias	Abacavirhydroxyacetate

Chemical Properties

Molecular Weight	344.37
Formula	C₁₆H₂₀N₆O₃
Cas No.	1446418-48-9
Smiles	Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](COC(=O)CO)C=C3)c2n1
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (232.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9039 mL	14.5193 mL	29.0385 mL	145.1927 mL
5 mM	0.5808 mL	2.9039 mL	5.8077 mL	29.0385 mL
10 mM	0.2904 mL	1.4519 mL	2.9039 mL	14.5193 mL
20 mM	0.1452 mL	0.7260 mL	1.4519 mL	7.2596 mL
50 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4519 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc