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7,4'-Di-O-methylapigenin

Catalog No. T5690   CAS 5128-44-9
Synonyms: 4',7-DIMETHOXY-5-HYDROXYFLAVONE

7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.

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7,4'-Di-O-methylapigenin Chemical Structure
7,4'-Di-O-methylapigenin, CAS 5128-44-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 84.00
10 mg In stock $ 123.00
25 mg In stock $ 198.00
50 mg In stock $ 297.00
100 mg In stock $ 462.00
1 mL * 10 mM (in DMSO) In stock $ 94.00
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Purity: 99.4%
Purity: 98%
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Biological Description
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Description 7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
In vitro Antioxidant activity in terms of TRP (196.03 μg/mg GAE), DPPH assay (IC50-173.09 μg/mL), hydroxyl radical scavenging assay (IC50-20.42 μg/mL), inhibiting LDL oxidation (IC50-51.99 μg/mL) and to enhance SOD activity (25.3 %) was higher in ethyl acetate extract (EAP). Phenolic and flavonoid content was measured and showed a positive correlation with antioxidant activity. Presence of 4',7-DIMETHOXY-5-HYDROXYFLAVONE and piperine (Pip) in EAP was determined by HPTLC analysis and was isolated. 4',7-DIMETHOXY-5-HYDROXYFLAVONE inhibited α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Hypolipidemic effect of 4',7-DIMETHOXY-5-HYDROXYFLAVONE on mouse pre-adipocyte (3T3L1) cell lines also showed a dose dependent reduction on lipid droplet content and effective concentration range was determined as 1-2.5 μg/mL. Suggested that Piper longum fruits can provide a natural source of antioxidants with antidiabetic and anti obesity potential.
Cell Research Solvent extracts from Piper longum fruits using hexane, ethyl acetate, methanol, 70 % methanol-water were taken and 4',7-DIMETHOXY-5-HYDROXYFLAVONE was isolated from ethyl acetate extract. Antioxidant activity, glucose uptake potential and adipocyte differentiation assay was performed with extract and pure compound.
Synonyms 4',7-DIMETHOXY-5-HYDROXYFLAVONE
Molecular Weight 298.29
Formula C17H14O5
CAS No. 5128-44-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7 mg/mL (23.47 mM)

TargetMolReferences and Literature

1. Krishna M S , Joy B , Sundaresan A . Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4\"-dimethyl ether isolated fromPiper longumL[J]. Journal of Food Science and Technology, 2015, 52(6):3561-3570.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Traditional Chinese Medicine Monomer Library Glycometabolism Compound Library Human Metabolite Library Food as Medicine Compound Library Human Endogenous Metabolite Compound Library Plus Selected Plant-Sourced Compound Library Antiparasitic Natural Product Library Chinese Pharmacopoeia Natural Product Library

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Keywords

7,4'-Di-O-methylapigenin 5128-44-9 Metabolism Amylase inhibit Inhibitor 7,4' Di O methylapigenin 4',7-DIMETHOXY-5-HYDROXYFLAVONE 7,4'DiOmethylapigenin inhibitor

 

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