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3-Methyl-GABA

Name: 3-Methyl-GABA
Brand: TargetMol
SKU: T22509
Rating: 4.5 (1 reviews)

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Catalog No. T22509Cas No. 1216629-00-3

3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD).

3-Methyl-GABA

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Catalog No. T22509Cas No. 1216629-00-3

Pack Size	Price	Availability	Quantity
100 mg	$1,150	6-8 weeks

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Product Introduction

Bioactivity

Description	3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD).
In vitro	The activation of GAD exhibits stereoselectivity, preferring the R isomer of 3-methyl GABA over the corresponding S isomer [1].

Chemical Properties

Molecular Weight	522.59
Formula	C₂₀H₃₀N₂O₁₀S₂
Cas No.	1216629-00-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mM, Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9135 mL	9.5677 mL	19.1355 mL	95.6773 mL
5 mM	0.3827 mL	1.9135 mL	3.8271 mL	19.1355 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5677 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7839 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9568 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc