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3-Methyl-GABA

Name: 3-Methyl-GABA
Brand: TargetMol
SKU: T22509
Rating: 4.5 (1 reviews)

Catalog No. T22509 Copy Product Info

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3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD).

3-Methyl-GABA

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Catalog No. T22509

Cas No. 1216629-00-3

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	$1,150	6-8 weeks	6-8 weeks

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD).
In vitro	The activation of GAD exhibits stereoselectivity, preferring the R isomer of 3-methyl GABA over the corresponding S isomer [1].

Chemical Properties

Molecular Weight	522.59
Formula	C₂₀H₃₀N₂O₁₀S₂
Cas No.	1216629-00-3
Smiles	CC(CN)CC(O)=O.CC(CN)CC(O)=O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mM, Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9135 mL	9.5677 mL	19.1355 mL	95.6773 mL
5 mM	0.3827 mL	1.9135 mL	3.8271 mL	19.1355 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5677 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7839 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9568 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc