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3-Hydroxy agomelatine

Name: 3-Hydroxy agomelatine
Brand: TargetMol
SKU: T10114
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10114Cas No. 166526-99-4

Alias 3-Hydroxyagomelatine

3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders.

3-Hydroxy agomelatine

😃Good

Catalog No. T10114Alias 3-HydroxyagomelatineCas No. 166526-99-4

3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$58	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders.
Targets&IC50	5-HT2C receptor:3.2 μM, 5-HT2C receptor:1.8 μM (ki)
In vitro	Agomelatine and S 21517 have relatively strong affinity for 5-HT2C receptors, with Ki values of 0.21 μM and 0.13 μM, respectively, while their metabolite 3-Hydroxy agomelatine has a lower affinity, with a Ki value of 1.8 μM, which is about 10-fold lower than that of the former two. All three are antagonists at the 5-HT2C receptor, and the order of potency is S 21517 > agomelatine > 3-Hydroxy agomelatine. [1]
In vivo	In Wistar rats, 3-Hydroxy agomelatine, administered by intraperitoneal injection at doses ranging from 1.25 to 40 mg/kg, did not significantly affect penile erections induced by mCPP and Ro 60-0175. [1]
Synonyms	3-Hydroxyagomelatine

Chemical Properties

Molecular Weight	259.3
Formula	C₁₅H₁₇NO₃
Cas No.	166526-99-4
Smiles	O=C(NCCC1=CC(O)=CC2=CC=C(OC)C=C21)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (771.31 mM), Sonication is recommended.

H2O: 80 mg/mL (308.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8565 mL	19.2827 mL	38.5654 mL	192.8268 mL
5 mM	0.7713 mL	3.8565 mL	7.7131 mL	38.5654 mL
10 mM	0.3857 mL	1.9283 mL	3.8565 mL	19.2827 mL
20 mM	0.1928 mL	0.9641 mL	1.9283 mL	9.6413 mL
50 mM	0.0771 mL	0.3857 mL	0.7713 mL	3.8565 mL
100 mM	0.0386 mL	0.1928 mL	0.3857 mL	1.9283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc