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Microbiology&virology Antifection 2-(Hydroxymethyl)anthraquinone

2-(Hydroxymethyl)anthraquinone

Catalog No. TN1213   CAS 17241-59-7
Purity 98.00% Datasheet

2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc.

2-(Hydroxymethyl)anthraquinone, CAS 17241-59-7
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc.
Targets&IC50 Antifection,  
In vitro The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(Hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(Hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose.
Synonyms
Purity 98.00%
Appearance solid
Molecular Weight 238.20
Formula C15H10O3
CAS No. 17241-59-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pyloriJ Ethnopharmacol. 2006 Apr 21;105(1-2):255-62.

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