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2,3-dihydro-1H-indene-5-sulfonamide
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Catalog No. T8611Cas No. 35203-93-1
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
2,3-dihydro-1H-indene-5-sulfonamide
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Purity: 99.89%
Catalog No. T8611Cas No. 35203-93-1
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | In Stock | In Stock | |
| 5 mg | $125 | In Stock | In Stock | |
| 10 mg | $190 | In Stock | In Stock | |
| 25 mg | $313 | In Stock | In Stock | |
| 50 mg | $441 | In Stock | In Stock | |
| 100 mg | $596 | In Stock | In Stock | |
| 200 mg | $791 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $106 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:solid
Color:White
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Product Introduction
2,3-dihydro-1H-indene-5-sulfonamide AI Summary
2,3-dihydro-1H-indene-5-sulfonamide shows binding affinity towards human cloned carbonic anhydrase isoforms, including carbonic anhydrase I with a Ki value of 215.0 nM and carbonic anhydrase II with a Ki value of 52.0 nM. It also exhibits potent inhibitory activity against carbonic anhydrase isoforms 12, 14, and 7, with Ki values of 0.39 nM, 6.5 nM, and 5.1 nM respectively. Despite its significant enzyme inhibition profile, 2,3-dihydro-1H-indene-5-sulfonamide demonstrates no anticonvulsant activity in OF1 mice when tested at a dose of 50 mg/kg for protection against maximal electroshock-induced seizures after 2 hours. Additionally, it shows bioactivity in inhibiting the SARS-CoV-2 3CL-Pro protease by 21.54% at a concentration of 20 µM, although its antiviral activity against SARS-CoV-2 is minimal, evidenced by a slight inhibition of -0.1% at a 10 µM concentration after 48 hours of exposure to the virus..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor. |
| Molecular Weight | 197.25 |
| Formula | C9H11NO2S |
| Cas No. | 35203-93-1 |
| Smiles | NS(=O)(=O)C1=CC2=C(CCC2)C=C1 |
| Relative Density. | 1.337 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (114.07 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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