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1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
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Catalog No. TN1517Cas No. 221696-69-1
Alias Cochinchinenin A
1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood.
1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
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Purity: 98.81%
Catalog No. TN1517Alias Cochinchinenin ACas No. 221696-69-1
1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 5 mg | $94 | In Stock | In Stock | |
| 10 mg | $137 | In Stock | In Stock | |
| 25 mg | $232 | In Stock | In Stock | |
| 50 mg | $343 | In Stock | In Stock | |
| 100 mg | $493 | In Stock | In Stock | |
| 200 mg | $686 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $103 | In Stock | In Stock |
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Purity:98.81%
Appearance:Solid
Color:White
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| Description | 1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood. |
| In vitro | According to the operational definition of material basis for the efficacy of TCM established, the material basis of the modulation on the TTX-R sodium currents in DRG neurons of dragon??s blood was judged from the experimental results. The drug interaction equation of Greco et al. was used to assess the interaction of the three components extracted from dragon??s blood. This investigation demonstrated that dragon??s blood suppressed the peak TTX-R sodium currents in a dose-dependent way and affected the activations of TTX-R sodium currents. The effects of the combination of Cochinchinenin A, cochinchinenin B, and loureirin B were in good agreement with those of dragon??s blood. Although the three components used alone could modulate TTX-R sodium currents, the concentrations of the three components used alone were respectively higher than those used in combination when the inhibition rates on the TTX-R sodium currents of them used alone and in combination were the same. The combined effects of the three components were synergistic. |
| Synonyms | Cochinchinenin A |
| Molecular Weight | 286.32 |
| Formula | C17H18O4 |
| Cas No. | 221696-69-1 |
| Smiles | C(CCC1=CC=C(O)C=C1)(=O)C2=C(OC)C=CC=C2OC |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (174.63 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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