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(+)-Norfenfluramine hydrochloride

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Catalog No. T72114Cas No. 37936-89-3

(+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease.

(+)-Norfenfluramine hydrochloride
Other Forms of (+)-Norfenfluramine hydrochloride:

(+)-Norfenfluramine hydrochloride

😃Good
Catalog No. T72114Cas No. 37936-89-3
(+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction

Bioactivity
Description
(+)-Norfenfluramine hydrochloride, a significant liver metabolite of (+)-fenfluramine, functions as a selective agonist for the 5-HT 2B receptor (K i: 11.2 nM), effectively stimulating inositol phosphate hydrolysis and elevating intracellular Ca2+. It is utilized in research focusing on primary pulmonary hypertension and valvular heart disease.
Targets&IC50
5-HT2C receptor:324 nM (Ki), 5-HT2A receptor:1516 nM (Ki), 5-HT2B receptor:11.2 nM (Ki)
Chemical Properties
Molecular Weight239.67
FormulaC10H13ClF3N
Cas No.37936-89-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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