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(Rac)-BMS-816336

Catalog No. T12663 CAS T12663

(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid <a href="/target/Dehydrogenase" style="display: inline; color: #c13a36">Dehydrogenase</a> type 1 (11β-HSD1) enzyme inhibitor with IC 50 s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability [1].

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(Rac)-BMS-816336, CAS T12663

Pack Size	Availability	Price/USD	Quantity
50 mg	12-16 weeks	$ 1,487.00
100 mg	12-16 weeks	$ 2,388.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme inhibitor with IC 50 s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability [1].
Targets&IC50	mouse 11β-HSD1:68 nM , human 11β-HSD1:10 nM
In vivo	(Rac)-BMS-816336 (compound 6n) has good metabolic stability with the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively [1].

Molecular Weight	341.44
Formula	C21H27NO3
CAS No.	T12663

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.

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Keywords

(Rac)-BMS-816336 T12663 Metabolism Dehydrogenase (Rac)BMS816336 (Rac) BMS 816336 Inhibitor inhibitor inhibit

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