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Proquazone

Name: Proquazone
Brand: TargetMol
SKU: T28454
Price: 130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28454Cas No. 22760-18-5

Alias Proquazonum, Proquazona, Biarison, Arthrex

Proquazone (Arthrex) is a nonsteroidal anti-inflammatory agent.

Proquazone

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Purity: 98.23%

Catalog No. T28454Alias Proquazonum, Proquazona, Biarison, ArthrexCas No. 22760-18-5

Proquazone (Arthrex) is a nonsteroidal anti-inflammatory agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$130	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$349	In Stock	In Stock
25 mg	$589	In Stock	In Stock
50 mg	$842	In Stock	In Stock
100 mg	$1,160	In Stock	In Stock
500 mg	$2,330	-	In Stock
1 mL x 10 mM (in DMSO)	$223	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.23%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Proquazone AI Summary

Proquazone demonstrates a multifaceted pharmacological profile with notable activities in anti-inflammatory, analgesic, antiviral, and enzyme inhibition domains. It exhibits relative oral anti-inflammatory activity in the Evans Blue-Carrageenan pleural assay with a potency of 0.4 compared to indomethacin and shows significant inhibition of PG synthetase (IC50 = 70.0 nM) from bovine seminal vesicles. This compound effectively reduces carrageenan-induced edema in rats, has an ED30 of 10.0 mg/kg for anti-inflammatory action and 20.0 mg/kg for analgesic action when administered orally. However, it causes ulcers in mice at 30 mg/kg but shows no toxicity up to 500 mg/kg. Proquazone also shows inhibition of edema and is effective in inhibiting adjuvant-induced polyarthritis in rats. In antiviral assessments, Proquazone inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, although the inhibition percentages are relatively low (-4.92% and -0.02%, respectively). It also shows 9.765% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. The compound demonstrates moderate liver toxicity and potential as a COX-2 selective inhibitor with a Selectivity Index of 400 over COX-1. It also displays human HDAC6 inhibitory activities with enzymatic inhibition percentages of -10.31% and -6.06% with commercial and custom peptide substrates, respectively, and exhibits strong inhibition of EGFR with an IC50 of 2.0 nM. Despite binding to multiple receptors, Proquazone’s substantial activities are primarily inhibitory, with notable binding affinities against PTGS2, Ptgs1, and PDE4D enzymes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Proquazone (Arthrex) is a nonsteroidal anti-inflammatory agent.
Synonyms	Proquazonum, Proquazona, Biarison, Arthrex

Chemical Properties

Molecular Weight	278.35
Formula	C₁₈H₁₈N₂O
Cas No.	22760-18-5
Smiles	CC(C)n1c2cc(C)ccc2c(nc1=O)-c1ccccc1
Relative Density.	1.12g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (233.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5926 mL	17.9630 mL	35.9260 mL	179.6300 mL
5 mM	0.7185 mL	3.5926 mL	7.1852 mL	35.9260 mL
10 mM	0.3593 mL	1.7963 mL	3.5926 mL	17.9630 mL
20 mM	0.1796 mL	0.8981 mL	1.7963 mL	8.9815 mL
50 mM	0.0719 mL	0.3593 mL	0.7185 mL	3.5926 mL
100 mM	0.0359 mL	0.1796 mL	0.3593 mL	1.7963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc