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N’-Nitrosonornicotine

Catalog No. T36709 CAS 80508-23-2

N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2

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N’-Nitrosonornicotine Chemical Structure

N’-Nitrosonornicotine, CAS 80508-23-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	177.207
Formula	C9H11N3O
CAS No.	80508-23-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform: Slightly soluble

Methanol: Slightly soluble

References and Literature

1. Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2. Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N’-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)

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Keywords

N’-Nitrosonornicotine 80508-23-2 N’ Nitrosonornicotine N’Nitrosonornicotine inhibitor inhibit

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