mannoside

M4284 (M 4284) is a selective and orally active biphenyl mannoside FimH antagonist.

4-Aminophenyl-α-D-mannopyranoside, 98% (4-Aminophenylmannoside, 98%) is a synthetic glycoside primarily utilized as a molecular tool in biochemical research for investigating glycosylation processes and enzyme-substrate interactions.

PST3.1a is a selective inhibitor of Mannoside acetyl glucosaminyltransferase 5 (MGAT5), used for studying glioblastoma multiforme (GBM). PST3.1a inhibits TGF-βR and FAK signalling associated with doublecortin (DCX), increases OLIG2 expression, and suppresses the invasion and proliferation of GBM initiator cells (GICs).

ArMan is an aryl mannoside ligand that can be functionalized onto the surface of virus-like particles (VLPs) via click chemistry. VLPs can target DC-SIGN dendritic cells, promoting selective co-engagement of DC-SIGN and TLR7, and resulting in a TH1-type immune response. VLP-ArMan-OvaI/II significantly inhibits tumor growth in a mouse melanoma model.