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L-162,313 (Alias: L-162313, L162,313, L 162,313)
Catalog No. T27762 Copy Product Info
Purity: 98.21%
🥰Excellent
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.
L-162,313
Copy Product Info🥰Excellent
Catalog No. T27762
Alias L-162313, L162,313, L 162,313
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.
Cas No. 151488-11-8
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $595 | In Stock | In Stock | |
| 10 mg | $969 | In Stock | In Stock | |
| 25 mg | $1,430 | In Stock | In Stock | |
| 50 mg | $1,930 | In Stock | In Stock | |
| 100 mg | $2,500 | - | In Stock |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.21%
Appearance:Solid
Color:White
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Product Introduction
L-162,313 AI Summary
L-162,313 exhibits high affinity and potent inhibitory activity at both Angiotensin II receptor type 1 (AT1) and type 2 (AT2). The compound shows Ki values of 3.9 nM for AT1 and 2.8 nM for AT2, demonstrating a slightly higher affinity for AT2. It effectively inhibits Angiotensin II binding, with IC50 values of 1.1 nM for AT1 and 2.0 nM for AT2, indicating its strong antagonist activity. Additionally, L-162,313 displays a ratio of binding affinity at AT1 compared to AT2 of 1.3. Beyond modulating the angiotensin system, it also exhibits diverse bioactivities, including antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 7943.28 nM to 12589.25 nM after 72 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. |
| Synonyms | L-162313, L162,313, L 162,313 |
| Molecular Weight | 582.78 |
| Formula | C30H38N4O4S2 |
| Cas No. | 151488-11-8 |
| Smiles | C(N1C=2C(N=C1CC)=C(C)C=C(C)N2)C3=CC=C(C=C3)C4=C(S(NC(OCCCC)=O)(=O)=O)SC(CC(C)C)=C4 |
| Relative Density. | 1.26 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (85.8 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (4.29 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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